The most frequently arising recurrent genetic changes in neuroblastoma are amplification of the oncogene MYCN and amplification/gain-of-function mutations of ALK (anaplastic lymphoma kinase).6–11 Mouse and zebrafish models demonstrated that both MYCN and activating mutant ALKF1174L can promote tumorigenesis.12–15 However, how ALK and MYCN conspire to accelerate tumorigenesis remains incompletely understood. The gene discussed is ALK; the disease is neuroblastoma.