The Cancer Genome Atlas (TCGA) data analysis and of our own patient data show that ACC is one of the tumors with the lowest SLFN11 expression (Supplementary Fig. S5; ref. 44), which may explain the activity of TAK-243 compared with DNA-targeted genotoxic agents that are generally less active in the large fraction of cancers that do not express SLFN11 (45). Here, SLFN11 is linked to cancer.