In line with most neurodegenerative disorders, post-mortem central nervous tissue of FTD and ALS cases both exhibit gliosis and aggregated protein deposits.15 These protein aggregates are frequently ubiquitinated and labelled with the autophagy receptor p62 (encoded by SQSTM1), as part of the cell’s attempt to target the misfolded proteins for degradation.16 However, the main protein constituents of the deposits vary and are used to classify cases into pathological subtypes. Here, SQSTM1 is linked to frontotemporal dementia.