Additionally, by 24 months of age, synaptophysin distribution was altered in the NMJs of this mouse model, with synaptophysin staining noticeably more punctate in mutant CHMP2B NMJs, suggesting a decrease in the number of synaptic vesicles in the NMJ of the CHMP2B FTD model.131. This evidence concerns the gene CHMP2B and frontotemporal dementia.