Expression of human FUS (wild-type or mutant) was additionally found to modify the size, position and docking of synaptic vesicles at the NMJ.169 A zebrafish model for FUS ALS, where the fus orthologue is deleted, displayed impaired motor abilities, decreased motor neuron length and fragmentation of the NMJ,170 suggesting that loss of FUS can also affect presynaptic pathology. Here, FUS is linked to amyotrophic lateral sclerosis.