Synaptopathy in CHMP2B FTD was first reported in Drosophila motor neurons expressing FTD-causative CHMP2BIntron5, which show significant aberrant synaptic overgrowth at the neuromuscular junction (NMJ).127 Synaptopathy has also been reported in mouse models of CHMP2B FTD. The gene discussed is CHMP2B; the disease is frontotemporal dementia.