Chronic deep brain stimulation in 3xTg-AD transgenic mice (which contain the MAPT P301L mutation in addition to mutations in APP and PSEN1) resulted in reduced levels of tau oligomers and increased levels of synaptophysin compared to non-stimulated mice, as quantified by confocal immunofluorescence in the hippocampal CA1 region. This evidence concerns the gene MAPT and Alzheimer disease.