Although it is not yet clear how LLPS contributes to synaptopathy, recent evidence shows that at the presynaptic terminal, tau undergoes activity-dependent LLPS to form nanoclusters that selectively control the mobility of recycling vesicles.250 As multiple other LLPS-associated proteins implicated in FTD and ALS are also found at the presynaptic terminal, the impact of these nano-biomolecular condensates on the physiology and pathophysiology of the presynaptic terminal warrants further investigation. The gene discussed is MAPT; the disease is amyotrophic lateral sclerosis.