ANXA11 and frontotemporal dementia: Crucially, the latter paper also identified the protein that connects RNA granules to the endolysosome as Annexin A11.228 Incredibly, Annexin A11 is a genetic cause of ALS, FTD and multisystem proteinopathy.229-231 The identification of Annexin A11 as the protein that attaches RNA granules to the endolysosome for distal transport in neurons posits this protein as both the physical and the metaphorical link between ALS and FTD, directly linking RNA biology and endolysosomal dysfunction.