EDN1 and hypertensive disorder: Combined with the understanding that ET-1 is expressed in the atria of SHR and DOCA-salt-induced hypertension rats more than in those of WKY [11, 12], and that hypertension is one of the significant factors for the square root of ET-1 expression in the human LAA [13], atrial expression of the ET-1 gene could play a role in blood pressure regulation in humans and rats.