Our research indicates that HPDL promotes tumor growth, migration and cell cycle in LUAD cells, and the administration of 4-Hydroxymethyl-2-furfural (4-HMA), 4-Hydroxybenzoic acid (4-HB), or Coenzyme Q10 (CoQ10) to patients bearing HPDL mutations may serve to ameliorate or stabilize certain symptomatic manifestations. Here, HPDL is linked to neoplasm.