Overall, the expression of HPDL showed a negative correlation with the level of immune infiltration from different types of infiltrating cells, including CAFs, lymphoid progenitors, myeloid progenitors, endo cells, HSCs, macrophages, mast cells, CD8+ T cells, CD4+ T cells, NKT cells, and g/dT cells, in various cancer forms. The gene discussed is CD8A; the disease is cancer.