AKT1 and breast cancer: For example, Goodarzi et al. have identified the new class of tsRNAs derived from several tRNA through hypoxic stress induction, these tsRNAs could bind to the 3'UTRs of YBX1 gene, which encoded an RNA-binding protein, then suppressed the stability of multiple oncogenic transcripts, including EIF4EBP1 and AKT1, results in the tumor-suppressive and metastasis-suppressive activities in breast cancers [12].