Study method and protocol of follow-up: Patients admitted with LUTS due to BPH were evaluated by scoring subjective symptoms with the help of the IPSS, QoLs, and IIEF questionnaires; physical examination and digital rectal examination (DRE) were performed; measurement of total serum prostate-specific antigen (PSA); USG KUB; and TRUS (trans-rectal ultrasound) measurement of prostate volume; PVR volume, and Qmax on uroflowmetry. The gene discussed is KLK3; the disease is benign prostatic hyperplasia.