KLK3 and Familial prostate cancer: Localized prostate cancer is confined to the prostate gland and does not grow into nearby tissues with clinical tumor node metastasis (TNM) stages cT1-T2 N0 M0 at presentation.3 Localized prostate cancer is further classified into low-, intermediate-, and high-risk groups of recurrence following radical treatment according to pretreatment variables of prostate-specific antigen (PSA), Gleason score, and clinical T stage.