Co-immunoprecipitation with each tagged H2A variant was differentially efficient at about 19% to 29% of that of cellular DNA for H2A, 39% to 47% for macroH2A, or 58% to 64% for H2A.B in untreated infections (Fig. 8E), again consistent with the previous experiments (Fig. 5 and 6). Here, PPIB is linked to infection.