CTLA4 and Autoimmunity: For example, active CD8+ T lymphocytes infiltrating healthy cardiac tissue and the consequent T‐cell‐mediated autoimmunity are strongly associated with fulminant myocarditis in melanoma and NSCLC patients receiving anti‐CTLA‐4/PD‐1 therapy, underscoring the pivotal relationship between antigen cross‐presentation and ICI‐induced myocarditis.36, 93