Together, these data revealed that (i) in APP/PS1 and WT mice, females have a somewhat longer TL but this pattern is not consistent across all tissue types; (ii) although APP/PS1 mice do not exhibit robust pathology between two sexes, the association between TL or MN with AD pathology is largely driven by female effects; and (iii) association between TL or MN with cognition decline in WT mice is largely driven by male effects. The gene discussed is APP; the disease is Alzheimer disease.