Thus, our results agree with the previous finding that there is a strong correlation between memory deficits and total Aβ loads, but not the Aβ42/Aβ40 ratio, in the brain of APP/PS1 mice (Savonenko et al., 2005), suggesting that the Aβ load is a reliable and robust predictor of cognitive deficits in APP/PS1 mice. Here, APP is linked to Cognitive impairment.