AGER and central precocious puberty: Considering that GL could inhibit extracellular activity of HMGB1 via binding to HMGB1 (Paudel et al., 2020; Shinde‐Jadhav et al., 2021), especially reducing HMGB1–RAGE interaction (Okuma et al., 2014), GL was used to determine the effect of HMGB1 on microglial activation during cocaine‐induced CPP.