BIN1 and Alzheimer disease: BIN1, the second most significant AD susceptibility gene in late-onset AD after APOE (Harold et al., 2009; Lambert et al., 2009; Seshadri et al., 2010) is expressed in neurons, microglia, and particularly in oligodendrocytes, and appears in different isoforms in the brain (Adams et al., 2016; De Rossi et al., 2016; Lambert et al., 2022).