In addition, human iPSC-derived microglia are able to phagocytose fibrillar Aβ as well as brain-derived tau oligomers resulting in an upregulation of a subset of tested AD-GWAS risk genes including ABCA7, CD33 and TREM2 or CD2AP, respectively (Abud et al., 2017). Here, MAPT is linked to Alzheimer disease.