BIN1 and Alzheimer disease: Since enlarged early endosomes have been described in AD neurons, and since endosomal pathway activation represents an early response in AD (Cataldo et al., 2000), it would be very interesting to assess the dynamics and cell autonomy of BIN1 isoform-mediated neurotoxicity in transplanted AD patient-derived or BIN1-engineered iPSC-derived neurons as well as BIN1 isoform-driven effects in stem cell-derived human microglia and especially oligodendrocytes in AD chimeric brains using stress-, activation- or myelination-specific fluorescent reporter constructs.