Neuronal loss and tangles as well as synaptic loss, neuroinflammation and cognitive impairment are seen in PS19 mice overexpressing the microtubule-associated protein tau (MAPT) harboring the MAPT-P301S mutation linked to frontotemporal dementia, an AD-related disease, and these mice have been used for modeling AD-like tau pathology while plaque pathology is expectedly not seen (Yoshiyama et al., 2007; Takeuchi et al., 2011). This evidence concerns the gene MAPT and frontotemporal dementia.