Important progress has also been made by generating humanized mice expressing the human sequences of Aβ or MAPT as in vivo models of tauopathy (Saito et al., 2014; Hashimoto et al., 2019; Saito et al., 2019; Baglietto-Vargas et al., 2021; Borcuk et al., 2022; Sasaguri et al., 2022). This evidence concerns the gene MAPT and tauopathy.