APP and Alzheimer disease: Other models like the 3xTg mice carrying the AD-associated APP-Swedish, MAPT-P301L and PSEN1-M146V mutations demonstrate formation of Aβ plaques and neurofibrillary tangles along with neuroinflammation, synaptic dysfunction, cognitive impairment (Oddo et al., 2003; Caruso et al., 2013).