They reported that PI enriched with solid predominant histological subtype (SPA) overexpressed the immune cell marker clusters, and its network is characteristically associated with enhanced IFNG signaling and inflammation, high tumor mutational burden (TMB), coupled with PD-L1 protein and CTLA4 RNA expression, and suggested that the PI subtype may have the subset of tumors most likely to respond to immune checkpoint inhibitors (38). Here, CTLA4 is linked to neoplasm.