When comparing cachectic versus non-cachectic patients on items representative of key cachexia domains, higher levels of CRP (median 37 versus 14 mg/dl, p < 0.001) and appetite loss (median score 4.0 versus 2.0, p < 0.001) and reduced food intake (76% versus 26%, p < 0.001) was observed for cachectic patients. The gene discussed is CRP; the disease is Cachexia.