According to the different break sites of the <i>PML</i> gene, there are three transcripts: Long (bcr1), Variant (bcr2) and Short (bcr3).<h4>Methods</h4>We retrospectively analyzed 82 APL cases with <i>PML-RARα</i> short isoform.<h4>Results</h4>A total of 384 patients with APL were seen, of which 85(22.14%) had <i>PML/RARα</i> short isoform (bcr3) and 82 met the inclusion criteria. The gene discussed is RARA; the disease is acute promyelocytic leukemia.