Some putative PPP2CA substrates we identified that have previously been linked to neurodevelopmental disorders include RING finger protein 12 ( RNF12), OTU deubiquitinase 5 (OTUD5), methyl CpG binding protein 2 (MECP2), microcephalin 1 (MCPH1), fragile X mental retardation protein (FMRP), Ser/Arg-rich splicing factor protein kinase 2 (SRPK2), and budding uninhibited by benzimidazoles 1 (BUB1).86 Here, BUB1 is linked to neurodevelopmental disorder.