It should be noted that recent studies on LRTC have already revealed its informative value in relation not only to affective disorders but also found increased DFA in neurodevelopmental disorders such as autism spectrum disorder (Bruining et al., 2020), STXBP1 syndrome (Houtman et al., 2021), and Rett syndrome (Sysoeva et al., 2023). The gene discussed is STXBP1; the disease is Down syndrome.