WBCs: white blood cells; IL-1β: interleukin-1β; IL-1RA: interleukin-1 receptor antagonist; WOMAC: Western Ontario and McMaster Universities Arthritis Index; APS: autologous protein solution; OMERACT-OARSI: Outcomes Measures in Rheumatology-Osteoarthritis Research Society International; IA: intra-articular; CGI-S/C: Clinical Global Impression of severity/change; KOOS: knee injury and osteoarthritis outcome score; NPRS: numeric pain rating scale; MRI: magnetic resonance imaging; KL: Kellgren-Lawrence. This evidence concerns the gene IL1B and arthritic joint disease.