Spp1+ Mac exhibited significant positive enrichment of up-regulated genes in foamy macrophages in scRNA-seq (scRNAseq_foamy_UP_nonfoamy_DOWN, NES = 3.22, p adj < 0.001) and bulk RNA sequencing (Bulk_RNAseq_foamy_UP_nonfoamy_DOWN, NES = 3.00, p adj < 0.001) datasets, as well as in tumor-specific SPP1+ macrophages (Tumor_specific_SPP1+_macrophages_UP, NES = 2.36, p adj < 0.001) (Figure 3A). The gene discussed is SPP1; the disease is neoplasm.