SPP1 and neoplasm: This enrichment was also observed in tumor-specific SPP1+ macrophages (Tumor_specific_SPP1+_macrophages_UP, NES = 2.5, p adj < 0.001) as well as in the Spp1+ LAM subset identified in the GSE227088 dataset (GSE227088 Spp1_LAM_UP, NES = 2.2, p adj < 0.001) (Figure 7D, Supplementary File 4).