Although a previous study showed that fused NUP98 proteins, i.e., NUP98-HOXA9 and NUP98-PMX1, interact with HDAC1 and are involved in the regulation of genes implicated in acute leukemia (46), our experiments with transiently expressed NUP98 indicate that unfused NUP98 might not interact with HDAC1. Here, PRRX1 is linked to acute leukemia.