To understand the impact of HIV-1 on the NPC components, we checked the expression of some of the NUPs such as NUP98, NUP62, NUP155, NUP133, NUP107, and NUP85 both in SupT1 (CD4+) and HEK293T cell lines, 4 days after infection with VSV-G (vesicular stomatitis virus envelope glycoprotein G)-pseudotyped HIV-1 virus (hereafter referred to as HIV-1 NL4.3). This evidence concerns the gene CD4 and infection.