Analysis of expression profiles indicated that ALDH1A1, BMP4 and EFNB2 were significantly higher in the patients with GDM compared with the normal samples (P<0.05 for ALDH1A1 and BMP4; P<0.01 for EFNB2) and MME, PLAUR and SLIT2 expression in normal samples was higher than that in patients with GDM (P<0.05 for MME, PLAUR and SLIT2) (Figure 7C). The gene discussed is BMP4; the disease is gestational diabetes.