ME2 and neoplasm: Upregulation of the p53 tumor suppressive pathway and mitochondrial respiration (up-PBT030-PPARGC1A, MCP1, PDP1, ME2, IDH3A, UQCR11, FAHD1, SOD2, and ATP6V1F), and glutamine metabolism (up-PBT030-PSAT1, GOT1, SERINC1; PBT147-ASNS, PYCR1, and PHGDH)—hallmarks of cell differentiation–were also observed at both time points, at both the 5- and 10-μM doses and in both cell lines (Supplementary Figure 2).