EPHB2 and central nervous system cancer: We demonstrated that BIRC5/Survivin gene expression was selectively downregulated and EphB2 was upregulated in our experiments in both human and mouse glioma cell lines post ICG-001 treatment, as shown by qPCR, which was further confirmed using a Survivin-luciferase reporter assay for PBT017 and PBT030 cell lines in vitro (Figure 2B).