Genotyping of HLA class I (HLA-A/B/C) and class II (HLA-DRB1/3/4/5 and HLA-DQB1/DPB1/DPA1/DQA1) genes was performed using NGS to establish possible connections with CLL. The gene discussed is HLA-DPB1; the disease is B-cell chronic lymphocytic leukemia.