Ma LY et al. (2011) found that youchasaponin (10, 20, 30 μg/mL for 24 h) induced apoptosis in human HCC cells HepG2 by upregulating the expression of IRE1, PERK, eIF2α and eEF2 proteins. The gene discussed is EIF2A; the disease is hepatocellular carcinoma.