Yan TH (2020) found that esculetin (0.28, 0.56,1.12 mmol/L for 48 h) dose-dependently upregulated GRP78, p-PERK, p-eIF2α, ATF-4, and CHOP expression in human GC cells SGC-7901, and this effect would be reduced by the ERS inhibitor Tauro ursodeoxycholic acid (TUDCA), implying that esculetin promotes apoptosis of tumor cells through oxidative stress with ERS. This evidence concerns the gene HSPA5 and neoplasm.