Zhang X et al. (2020) reported that RTR-1 (3.12, 6.25, 12.5, 25, 50, 100 μmol/L for 48 h) was able to increase the expression of IRE1α, CHOP, PERK, and BiP proteins in GC cells BGC-823 and SGC-7901, to block the cell cycle, to inhibit cancer cell growth and to induce apoptosis. The gene discussed is HSPA5; the disease is cancer.