Xu H et al. (2022) reported that berbamine(10, 20, 40, 80, 120, 160 μg/mL for 48 h) induced apoptosis in GC cells AGS via ERS pathway by dose-dependently upregulating the expression of Bax, CHOP, GRP78 and cleaved Caspase-12 and downregulating the expression level of Bcl-2. This evidence concerns the gene CASP12 and gastric cancer.