It was found that saponin fraction from Gleditsia sinensis (5, 10, 20 μg/mL for 24 h) dose-dependently upregulated GRP78 and CHOP protein expression in murine HCC cells H22, enhanced the anti-hepatocellular carcinoma effects of the chemotherapeutic drug sorafenib, inhibited HCC cell proliferation and induced apoptosis in HCC cells, which could be attenuated by ERS inhibitor TUDCA (Yin C et al., 2019). This evidence concerns the gene DDIT3 and hepatocellular carcinoma.