Shang J et al. (2023) reported that bufalin (2.5, 5, 10 nmol/L for 48 h) leaded to concentration-dependent upregulation of Bax, GRP78, p-PERK, p-eIF2α, and CHOP proteins expression, downregulation of Bcl-2 and eIF2α, inhibition of CRC cell proliferation, and induction of cancer cell apoptosis in HCT116 cells. This evidence concerns the gene EIF2A and cancer.