Li C et al. (2023) observed that dehydrodiisoeugenol (10, 20, 30, 40, 50, 60, 70, 80 μM for 24,48,72 h) dose-dependently upregulated BiP, Ero2-Lα, PERK, eIF2α, p-eIF1α, IRE1α, XBP-48s and CHOP expression in HCT116 and SW620 cells, blocking the CRC cell cycle at G1/S, inducing cell autophagy, and inhibiting cell proliferation and tumor growth. Here, ERN1 is linked to colorectal carcinoma.