Gu Q et al. (2021) found that wogonoside (10, 25, 50, 75 μM for 0, 6, 12, 24, 48, 72, 96 h) significantly upregulated expression of CHOP, GRP78, GRP94, IRE1α, TRAF1, p-ASK and p-JNK in AGS and MKN-45 cells, reduced cell viability and induced apoptosis in GC cells, and its biological effects could be blocked by IRE1α knockdown. This evidence concerns the gene HSPA5 and gastric cancer.