Cell experiments (12.5, 25, 50, 100 μmol/L for 24, 48, 72 h) and animal experiments (30 Μm/d for 4 weeks) in mice showed that furanocoumarins inhibit HepJ5 and Mahlavu cell viability and induce apoptosis in HCC cells in vitro and in vivo by upregulating PERK and CHOP (Huang TY et al., 2023). Here, EIF2AK3 is linked to hepatocellular carcinoma.