Quercetin (12.5, 25, 50, 100, 200, 400 μmol/L for 48 h) was found to cause a decrease in GRP78, Snail, and Vimentin mRNA and protein expression levels in HCC cells HepG2, inhibiting ERS and its epithelial mesenchymal transition to suppress the proliferation and metastasis of tumor cells (Li SS et al., 2017). This evidence concerns the gene HSPA5 and hepatocellular carcinoma.