Fang W et al. (2019) observed that oxymatrine (30, 60, 90 μmol/L for 24, 48, 72 h) upregulated intracellular GRP78/Bip and Caspase-12 gene and protein expression levels, inhibited cancer cell growth, and induced Caspase-12-dependent ERS apoptosis and G2/M phase cell block in GC cells BGC-823 in a time- and concentration-dependent manner. Here, CASP12 is linked to cancer.