Lu MJ and Chu WJ (2021) observed that the konjac glucomannan (50 μmol/L for 5 d) dose-dependently upregulated the protein levels of cleaved caspase-3, cleaved caspase-9, Bax, PERK, p-eIF2α, ATF4, and CHOP, and downregulated the protein level of Bcl-2, induced apoptosis, and reversed the resistance to 5-Fluorouracil (5-FU) in CRC cells HCT-28. The gene discussed is ATF4; the disease is colorectal carcinoma.