In the present study, the ANN model built based on 10 indicators such as age, history of hypertension, history of malignant tumor, baseline platelet value, TP, ALB, AST, DBIL, Urea and Ccr could effectively predict the risk of linezolid-induced platelet reduction, with an accuracy of 96.32%, which was significantly higher than that of Logistic regression model. This evidence concerns the gene ALB and Hypertension.