The patterns for GEX of the genes and multigene signatures were in general either that GEX; 1) successively decreased through tumor progression, which was observed mainly in signatures associated to a less aggressive tumor type, including mast cells, ER signaling, and PGR, or 2) increase in GEX in LNM compared to PT, often to decrease below the PT level in DM, the pattern of most immune-related signatures, including APM, cytotoxic cells, IDO1, PD1, PDL1/2, TIGIT, TIS, and T-reg, as well as the apoptosis signature. Here, ESR1 is linked to neoplasm.