GHRL and colitis: Cheng et al. (2016) employed ghrelin as a therapeutic intervention for rats with ICH and observed that ghrelin exhibited the ability to enhance the expression of CLDN-5 protein and ZO-1 protein, thereby suggesting a beneficial impact on the restoration of intestinal barrier function in ICH rats. Another plausible mechanism through which ghrelin may facilitate the repair of the intestinal barrier in rats is by inhibiting NF-κB. Cheng et al. (2015) employed ghrelin as a therapeutic intervention for colitis-afflicted rats.