Besides its anti-diabetic effect, metformin has been shown to have neuroprotective effects in experimental stroke (Li et al., 2010), against ethanol-induced neuronal apoptosis (Ullah et al., 2012), alpha-synuclein neurotoxicity (Dulovic et al., 2014) and MPTP- and rotenone-induced DAergic neurodegeneration (Patil et al., 2014; Lu et al., 2016; El-Ghaiesh et al., 2020; Wang et al., 2020). The gene discussed is SNCA; the disease is Stroke.