The meta-analysis indicated that the serum MMP-9 levels at 1–3, 24, and 72 h after seizure in female (1–3 h: SMD = 4.60, 95% CI = −1.29–10.49, p = 0.13; 24 h: SMD = 1.95, 95% CI = −0.44–4.34, p = 0.11; 72 h: SMD = 0.74, 95% CI = 0.08–1.39, p = 0.03; Figure 3D) and male (1–3 h, SMD = 4.60, 95% CI = −1.29–10.49, p = 0.13; 24 h: SMD = 1.95, 95% CI = −0.44–4.34, p = 0.11; 72 h: SMD = 0.74, 95% CI = 0.08–1.39, p = 0.03; Figures 3D,E) epilepsy patients showed no substantial difference between with the control groups. Here, MMP9 is linked to epilepsy.