Methylation of FKBP5 is also known to decrease with aging in humans, and in a model of replicative senescence, the in vitro aging-induced decline in FKBP5 methylation was exacerbated by GC exposure and the subsequently increased FKBP5 expression was associated with inflammation and myocardial infarction (Zannas et al., 2019). The gene discussed is FKBP5; the disease is myocardial infarction.