LASSO regression for the training cohort identified 12 variables associated with sepsis prognosis out of 45 clinical parameters (Additional file 3: Fig. S3): Age, Heart rate, AST, invasive ventilation treatment, renal replacement treatment, albumin, cerebrovascular disease, MHR, NLR, NHR, BUN, and Potassium. The gene discussed is ALB; the disease is cerebrovascular disorder.