The ewECG screening features were predictive for SBHF in the validation dataset (AUC = 0.81, 95%CI 0.787–0.794), outperforming both NT-proBNP and ARIC HF risk score significantly, with a sensitivity of 89% and specificity of 62% (Fig. 2). The gene discussed is NPPB; the disease is hydrops fetalis.