To understand whether the acquisition of the chemoresistant phenotype in A2780 cells treated EVs from A2780 CIS cells was accomplished by RAB7 downregulation, we analyzed expression levels of this small GTPase after treatment with (i) conditioned medium from A2780 CIS cells, (ii) EVs derived from A2780 CIS cells, (iii) conditioned medium from A2780 CIS cells deprived of EVs and conditioned medium derived from A2780 CIS cells treated with GW4869 (Fig. 8C, D). Here, RAB7A is linked to in situ carcinoma.