TP53 and in situ carcinoma: Finally, it may be also noted that the CDDP-resistant A2780 CIS cell line, which we used as a model in this study, harbors the K351N substitution in p53 that has been shown to impair ubiquitination of p53, and CDDP-induced translocation of p53 to mitochondria [49], while SKOV-3 are described as p53-null cell lines [82].