They are predicted to contribute to cardiovascular malformations (SUZ12, ADAP2), higher malignant potential (UTP6, ATAD5, SUZ12, RNF135, COPRS, MIR193A, MIR365B), overgrowth (RNF135, SUZ12), intellectual disabilities (OMG, RNF135, SUZ12, CRLF3). The gene discussed is SUZ12; the disease is Intellectual disability.