They are predicted to contribute to cardiovascular malformations (SUZ12, ADAP2), higher malignant potential (UTP6, ATAD5, SUZ12, RNF135, COPRS, MIR193A, MIR365B), overgrowth (RNF135, SUZ12), intellectual disabilities (OMG, RNF135, SUZ12, CRLF3). Here, OMG is linked to Intellectual disability.