Douglas et al. [57] identified in 2007 a truncating mutation or complete deletion of RNF135 in 5 individuals out of 245 unrelated individuals with overgrowth and learning disabilities, plus one patient with a missense variant in RNF135. Though this result was suggestive of a direct implication of RNF135 in overgrowth pathogenesis, Visser et al. [58]. The gene discussed is RNF135; the disease is learning disability.