COPRS and Intellectual disability: They are predicted to contribute to cardiovascular malformations (SUZ12, ADAP2), higher malignant potential (UTP6, ATAD5, SUZ12, RNF135, COPRS, MIR193A, MIR365B), overgrowth (RNF135, SUZ12), intellectual disabilities (OMG, RNF135, SUZ12, CRLF3).