In addition, we identified 45 novel pathogenic variants in the genes NYX, CACNA1F, TRPM1, and GRM6. High myopia was more frequent in patients with NYX, but the rate of progression was not greater in patients with NYX than in those with TRPM1. The possible pathophysiology related to different myopic progression in CSNB patients may be due to the background of different gene variants. This evidence concerns the gene TRPM1 and myopia.