Ultra-low doses of LPS can induce specific persistent inflammatory state and PE-like clinical symptoms in pregnant rats, such as hypertension, proteinuria, thrombocytopenia, etc. Therefore, in this paper, the human transformed primary extravillous trophoblast cell line (HTR8/SVneo) was stimulated by LPS to establish a PE inflammatory cell model, and to explore whether miR-223 could regulate the inflammatory response in the PE placenta by targeting NLRP3. The gene discussed is NLRP3; the disease is hypertensive disorder.