MIF and neoplasm: For instance, the expression of MIF, CD74, and CXCR4 were predominantly upregulated in myeloid cells, but CD44 was predominantly downregulated in myeloid cells (Fig. 5D); the expression of MHC-II molecules, including HLA-DRA, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DMA, HLA-DMB, HLA-DQB1, HLA-DRB5 and HLA-DRB were all activated mainly in myeloid cells of the tumor group (Fig. 5E); CXCL was most downregulated in cells except T cells (Supplementary Fig. 4D); CD8A was most downregulated in T cells (Supplementary Fig. 4E).