KEGG and GO analyses of these 69 genes revealed their roles in immune-related functions, for example, the IL-17 signaling pathway, primary immunodeficiency, the T cell receptor signaling pathway, PD-L1 expression, and the PD-1 checkpoint pathway in cancer, MHC-II protein complex binding, MHC-II receptor activity, and cytokine activity (Fig. 5G & Supplementary Fig. 4F). The gene discussed is CD274; the disease is inborn error of immunity.