The regulons activity of FLI1 and most of its cofactors (ELF1, ELK1, ELK3, ELK4, ERF, ERG, ETS1, ETS2, ETV1, ETV2, ETV3, ETV4, FEV, ELF4, ETV3L, ETV7, SPDEF) indicated obvious enrichment in endothelial cells and immune cells (B cells, T cells, and myeloid cells) in normal tissues; however, those regulons activities of FLI1 and some cofactors (ELF1, ELK1, ELK3, ELK4, ETS2) was lost in tumor tissues (Fig. 3E & Supplementary Fig. 2D). This evidence concerns the gene ELK4 and neoplasm.