FLI1 undergoes translocation with the Ewing sarcoma gene, thus leading to a fusion gene driving Ewing sarcoma by either transcriptionally inducing or repressing specific target genes, such as the RAS antagonist Sprouty 1 [6], E2F [7], and NOTCH-activated p53 [8]. The gene discussed is FLI1; the disease is Ewing sarcoma.