In HCT116 CRC cells, treatment with Fn followed by microarray analysis identified that Fn stimulates the Toll-like receptor 4 (TLR4) signaling to MYD88, which may be mediated through the binding of Fn lipopolysaccharide (LPS) to TLR4 [92], leading to activation of the nuclear factor κB (NF-κB). This evidence concerns the gene FN1 and colorectal carcinoma.