The effect of Fn on cancer cells appears to depend on the tumor type, as coincubation with Fn significantly stimulated the growth of several in vitro CRC cells, such as AA/C1/SB10C, HCT116, DLD1, SW480, and HT29 CRC cells [82, 86], but did not stimulate the growth of lung cancer (PC-9), prostate cancer (22RV1), bladder cancer (UMUC3), or breast cancer (MCF-7) cells [82]. Here, FN1 is linked to breast cancer.