HDAC inhibition increases the recruitment of AhR to its target gene CYP1A1’ promoter through the reshaping of chromatin and enhancing the expression of AhR-responsive genes CYP1A1, CYP1B1, AhR repressor in Caco-2 CRC cells and YAMC mouse colonic epithelial cells [143, 144]. Here, CYP1A1 is linked to colorectal carcinoma.