In turn, NF-κB upregulates the oncogenic miRNA-21 promoter activity, which reduces the levels of the RAS GTPase-activating protein (RASA1), a tumor suppressor that inactivates the oncoprotein RAS [93], a well-known activator of the Ras/Raf/MAPK pathway [94]. Here, NFKB1 is linked to neoplasm.