Furthermore, since most studies have focused on Fn, further research is required on the possible crosstalk between AhR and other bacterial species implicated in CRC, such as Sg, ETBF, Escherichia coli B2, Enterococcus faecalis, and Peptostreptococcus anaerobius. Additionally, the role of the microbiome in promoting immune responses and responsiveness to immunotherapy and the relevance of possible future investigations in light of the role of AhR need further investigation. This evidence concerns the gene FN1 and colorectal carcinoma.