There could also be potential crosstalk between miRNA-21 and the Wnt/β-catenin pathway, as miRNA-21 knockdown in mice was found to significantly decrease tumor size and number, increase E-cadherin level, and decrease the expression of β-catenin, NF-κB, signal transducer and activator of transcription-3 (STAT3), Bcl-2, and SOX-9 [95]. Here, STAT3 is linked to neoplasm.