Zhou et al. recently discovered variants in 10 distinct MIPs (FAM166A, CCDC105, TEX37, EFCAB6, EFHC2, FAM166C, MNS1, TEKT1, CFAP45, and CFAP21) associated with a subtype of asthenozoospermia termed MIP-variant-associated asthenozoospermia (MIVA), which is characterized by impaired sperm motility without evident morphological abnormalities [11]. The gene discussed is CFAP45; the disease is Reduced sperm motility.