Among the recognized pathophysiological mechanisms implicated in COVID-19-related coagulopathy, there are hypo-fibrinolytic changes typified by increased production of plasminogen activator inhibitor-1 (PAI-1) by inflammatory agents process, which is accompanied by impaired degradation of PAI-1 due to inhibition of protein C [119, 126]. Here, SERPINE1 is linked to COVID-19.