While SSc affects certain organs via inflammation, fibrosis, and vasculopathy, its exact pathophysiology remains elusive. Many cytokines, chemokines, and growth factors have been investigated for their potential involvement in the pathogenesis of SSc. In particular, interleukin (IL)-6 appears to play a key role in inflammation and fibrosis, and its serum levels were reported to reflect skin fibrosis and correlate with modified Rodnan skin score (mRSS) in SSc. This evidence concerns the gene IL6 and systemic sclerosis.