RHEB and cancer: Consistent with these data, expression of WT ATP6AP1 but not the two mutants in ATP6AP1-knockdown cells could restore proliferation (Fig. 7c), anchorage-independent growth (Fig. 7d, e), and migration (Fig. 7f, g; Supplementary information, Fig. S8d, e), providing further evidence that the Rheb GEF activity of ATP6AP1 is critical for cancer cell proliferation and migration.