ABCG8 and Intrahepatic cholestasis of pregnancy: Seven metabolic trait-associated loci (GCKR, ABCG8, ABCB11, ABCB1, CYP7A1, SERPINA1 and HNF4A) were associated (P < 5 × 10−8) with risk of intrahepatic cholestasis of pregnancy (ICP) in FinnGen (Fig. 3a and Supplementary Table 12), of which all except ABCG8 showed robust evidence of colocalization or shared regional associations with the metabolic trait associations (Supplementary Table 13).