ITGAM and neoplasm: To this end, Siglec expression on tumor-infiltrating and spleen-derived MDSCs from tumor-bearing and naïve mice was assessed by analyzing the CD11b+Ly6G+ and CD11b+Ly6C+ populations, which, in the tumor context, are described as gMDSCs and mMDSCs, respectively [18] (Fig. S1, F).