Tumor growth was not significantly different among SigEΔLysM and SigEWT mice injected with B16F10 GNE KO cells and mice injected with the B16F10 wild-type cells, suggesting a Siglec-E-dependent effect in our model involving sialylated glycans on cancer cells (Fig. S4, M–O). This evidence concerns the gene GNE and neoplasm.