CD8A and cervical adenocarcinoma: Using lung adenocarcinoma A549 and cervix adenocarcinoma HeLa cell lines, we generated highly immunosuppressive MDSC-like cells from fresh peripheral blood mononuclear cells (PBMCs) that were able to decrease CD8+ T-cell proliferation in an effector:target (E:T) ratio-dependent manner (Fig. S5A).