EAA showed strong binding affinity to exosomes from different origins and enabled efficient loading of coagulation factor IXa (FIXa) antagonist RNA aptamer (9.3t), thrombin DNA aptamer inhibitor NU172 (Keefe et al, 2010; Rusconi et al, 2002) or Duchenne Muscular Dystrophy (DMD) phosphorodiamidate morpholino oligomer (PMO) drug, an antisense oligonucleotide (AO) targeting at murine dmd exon 23 (Bauman et al, 2009), on murine myotube-derived exosomes via annealing or direct synthesis. Here, DMD is linked to Duchenne muscular dystrophy.