IL2 and neoplasm: In mice, the targeted delivery of IL2, TNF, and IL12 led to a potentiation of the cytokine payload as a result of increased density and activity of tumor resident T cells and NK cells, capable of neoplastic cell recognition (Halin et al, 2002; De Luca et al, 2017; Puca et al, 2020; Weiss et al, 2020; Look et al, 2023).