Among dozens of cytokine payloads, IL2, IL12, and TNF have emerged as some of the most efficient immunomodulatory proteins in preclinical models of cancer (Halin et al, 2002; De Luca et al, 2017; Puca et al, 2020; Weiss et al, 2020; Look et al, 2023). Here, IL2 is linked to cancer.