As the expression pattern in tumor, the CXCL9, -10, -11/CXCR3 axis impacts TAMs polarization. However, immune cells, show anti-tumor effect against cancer cells through paracrine CXCL9, -10, -11/CXCR3 axis, the autocrine CXCL9, -10, -11/CXCR3 signaling in cancer cells increases cancer cell proliferation, angiogenesis, and metastasis38. Here, CXCR3 is linked to neoplasm.