Mouse datasets included microglia from control mice and mouse models of amyloid deposition (i.e AppNL-G-F, APP/PS1, and 5XFAD), microglia from aging and demyelinating brains (i.e., upon cuprizone treatment), macrophages from atherosclerotic plaques, macrophages from adipose tissue of healthy and obese mice, and Kupffer cells from healthy, non-alcoholic steatohepatitis (NASH), and cirrhotic livers6,9,14,20,21,26–29. This evidence concerns the gene APP and metabolic dysfunction-associated steatohepatitis.