SPI1 and Alzheimer disease: We and others have also previously shown that AD heritability is enriched within PU.1 (proxy- as well as ChIP-seq) binding sites in macrophages/microglia and that AD risk alleles in the SPI1 AD GWAS locus affect PU.1 expression, further implicating this DLAM TF in the modulation of AD risk4,33,35.