Integration of multiple microglial bulk microarray datasets, including transcriptome profiles of microglial cells acutely isolated from AD mouse brains led to the identification of potential regulators of several microglial transcriptional states and identified Cebpα, Irf1, and Lxrα/β as positive transcriptional regulators of DLAM markers such as Apoe, Cxcr4, and Trem217,18. Here, APOE is linked to Alzheimer disease.