We and others have also previously shown that AD heritability is enriched within PU.1 (proxy- as well as ChIP-seq) binding sites in macrophages/microglia and that AD risk alleles in the SPI1 AD GWAS locus affect PU.1 expression, further implicating this DLAM TF in the modulation of AD risk4,33,35. The gene discussed is TF; the disease is Alzheimer disease.