SPI1 and Alzheimer disease: In addition to SPI1/PU.1, we uncovered a significant enrichment of AD risk alleles in the proxy-cistrome of BHLHE41 in human microglia and monocyte-derived macrophages (P value = 2.2e-03 and 6.8e-03, respectively), implicating its target gene network in AD risk modification (Fig. 2A, B).