MCOLN1 and Parkinson disease: For instance, celastrol has been confirmed to exerts neuroprotection in PD by activating mitophagy to degrade impaired mitochondria and further inhibit dopaminergic neuronal apoptosis42, and Artemisia Leaf Extract can exert neuroprotective effects by stimulating TRPML1 and rescuing neuronal cells by boosting autophagy/mitophagy and upregulating a survival pathway43.